For noninfectious diarrhea in adults living with HIV who are on ART
An antisecretory antidiarrheal that:
- Works by normalizing fluid and electrolyte balance in the GI tract to provide symptomatic relief of diarrhea
- Is not an opioid and does not affect GI motility
Minimally absorbed, well-tolerated, and demonstrated to have:
- No clinically relevant drug-drug interactions
- No effect on viral load or CD4 counts
- Adverse events comparable to those with placebo
NOVEL ANTIDIARRHEAL MECHANISM
Mytesi, which regulates two chloride ion channels in the intestinal lumen (CFTR and CaCC), normalizes fluid and electrolyte balance in the GI tract—with a very low risk of constipation
For noninfectious diarrhea in adults living with HIV who are on ART
Mytesi—The only FDA-approved treatment for symptomatic relief of diarrhea in people with HIV
Results over time with Mytesi2†
Week 4 on Mytesi 125-mg BID
61% of patients had at least a
50% decrease in watery stools
Week 20 on Mytesi 125-mg BID
83% of patients had at least a
50% decrease in watery stools
†Daily diary data were evaluated in a supplemental analysis from all patients treated with Mytesi 125-mg BID in the ADVENT trial for up to 24 weeks. The average reduction in watery stools from baseline was determined by week.
Know when your patients have had ENOUGH.
NapoCares™️ Patient Support
Connect your eligible adult patients living with HIV-related diarrhea to resources that help them access Mytesi.
Eligible patients may enroll in the Mytesi Copay Savings Program and download their Mobile Savings Card at napocares.com today.
You may also enroll your eligible‡ patients in the Mytesi Copay Savings Card program by calling NapoCares at (888) 527-NAPO (6276), Monday-Friday, 8 am-5 pm CST.
‡Patient must have commercial insurance for eligibility. Restrictions apply. Rx only. Subject to change or cancellation at any time and without notice.
- Gehrig M, Clay P, Perry R, et al. Actual versus perceived use of pharmacokinetic (primarily absorption) influential OTC agents and ART tolerability in a nationwide matched cohort of HIV patients and their healthcare providers. Poster abstract presented at: ID Week 2016; October 26-30, 2016; New Orleans, LA.
- MacArthur RD, Clay P, Blick G, et al. Long-Term Crofelemer Provides Clinically Relevant Reductions in HIV-Related Diarrhea. Poster presented at: 9th IAS Conference on HIV Science (IAS 2017); 2017 July 23-26; Paris, France.